C3/C3a, Human, mAb 474 - HM2073-100UG

Understanding Complement Protein C3/C3a and its Role in Innate Immunity The complement system, a crucial component of innate immunity, includes a pivotal element known as complement protein C3/C3a. This protein plays a central role in the classical, alternative, and lectin pathways of complement activation, underlining its importance in the immune response. The Synthesis and Function of Complement Protein C3/C3a Complement protein C3/C3a is synthesized in a tissue-specific manner, influenced by various stimulatory agents. A significant aspect of C3/C3a's function involves its cleavage during complement activation. This cleavage releases C3a, an anaphylatoxic peptide consisting of 74 amino acids, approximately 10 kDa in size. C3a, known for its transient nature in serum, is quickly converted into a more stable form, C3a-desArg (also referred to as acylation stimulating protein, ASP). C3a's Mechanism of Action C3a operates through a specific receptor, C3aR, belonging to the G-protein coupled receptor family. This receptor's expression across various cell types, including myeloid and non-myeloid cells, underscores its broad impact. Notably, C3aR's presence on hematopoietic stem/progenitor cells enhances their trafficking to the bone marrow. Additionally, C3aR's engagement with dendritic cells (DCs) and T cells has been shown to augment their functions. C3a's Role in Inflammatory Processes Complement protein C3/C3a, particularly C3a, is a key mediator in local inflammatory processes. It induces smooth muscle contraction, increases vascular permeability, and prompts histamine release from mast cells and basophilic leukocytes. The involvement of C3a in inflammatory responses is evident in conditions such as gram-negative bacterial sepsis, ischemic heart disease, and various autoimmune diseases. Not sure which C3 antibody to use? With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision: Go to our C3 researcher’s guide and choose the right antibody