C3a, Mouse, mAb 3/11 - HM1072-100UG

Quantity
100 µg
Catalog #
HM1072-100UG
533,00 €
The monoclonal antibody 3/11 recognizes C3a, an activated fragment of the complement protein C3, a 190 kDa protein which is the most abundant complement protein in serum. C3 is the third component of the complement system and plays a central role in the complement cascade. The three pathways of compliment activation come together- at this key molecule. Cleavage of the pivotal complement component C3 results in the generation of a set of effector molecules which have diverse biological functions. The cleavage product C3b promotes complement acrtivation and the subsequent formation of the membrane attack complex. C3a, the small (ca. 10 kDa) cleavage product possesses anaphylatoxic as well as immunoregulatory- properties. It exerts its function through a specific receptor (C3aR), which belongs to the G-protein coupled receptor family. Expression of C3aR- has been reported in many cell types including myeloid and non-myeloid cells. Expression of C3aR on haematopoietic stem/progenitor cells has been shown to promote the trafficking/homing of these cells to the BM. Engagement of C3aR on DCs and T cells has been shown to up-regulate these cell functions. The monoclonal antibody 3/11 reacts specifically with the C3a anaphylatoxin, providing a tool for monitoring acute complement activation (C3a generation) in experimental mouse models.
Weitere Informationen
Datasheet URL https://www.hycultbiotech.com/wp-content/uploads/2022/06/coa-tds_hm1072-100ug.pdf
Quantity 100 µg
Quantity 100 µg
Species MOUSE
Application Flow cytometry, Functional studies, Immuno assays, Western blot
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
References 1. Mastellos, D et al; Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. Mol Immunol 2004, 40: 1213
2. Markiewski, M et al; C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. J Immunol 2004, 173: 747
3. Park, J et al; Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. Am J Respir Crit Care Med 2004, 169: 726
4. Nozaki, M et al; Drusen complement components C3a and C5a promote choroidal neovascularization. PNAS 2006, 103: 2328
5. Pritchard, M et al; Differential contributions of C3, C5 and decay accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 2007, 132:1117
Disease Infectious diseases, Nephrology
Applications
Application: Flow cytometry Functional studies Immuno assays Western blot
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