C5a/C5a des Arg, Human, mAb 2952 – 100 µg - HM2079-100UG
Quantity
100 µg
Catalog #
HM2079-100UG
414,00 €
Monoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8. General comment: Please notice that under given conditions it is known that C5 can expose epitopes normally only found in the cleaved activation products (ref.5).
| Datasheet URL | https://www.hycultbiotech.com/wp-content/uploads/2022/06/coa-tds_hm2079-100ug.pdf |
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| Quantity | 100ug |
| Quantity | 100 µg |
| Species | human |
| Application | Frozen sections, Functional studies, Immuno assays, Western blot |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
| References | 1. Hartmann, H et al; ;Rapid quantification of C3a and C5a using a combination of chromatographic and immunoassay procedures. J Immunol Meth 1993, 166: 35 2. Kola, A et al; Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display, synthetic peptides and site-directed mutagenesis. Immunotech 1996, 2: 115 3. Stöve, S et al; Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome. Clin Diag Lab Immunol 1996, 3: 175 4. Nozaki, M et al; Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci USA 2006, 103: 2328 5. Nilsson, P et al, A novel human whole blood model preventing fibrin formation reveals that thrombin does not cleave C5 under physiological conditions. Abstract Mol Imunol 2018, 102: 194 |
| Disease | Infectious diseases, Nephrology |
| Application: | Frozen sections Functional studies Immuno assays Western blot |
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