(R)-CR8 - HY-18340
10mM
Nur noch %1 verfügbar
Catalog #
HY-18340
Ab
186,00 €
(R)?-?CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)?-?CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)?-?CR8 induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K[3].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-18340/R-CR8-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-Kinase/protease |
| Alternative Names | CR8, (R)-Isomer |
| CAS | 294646-77-8 |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 431.53 |
| Solubility | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
| Clinical Information | No Development Reported |
| Target | Apoptosis;CDK;Molecular Glues |
| Application: | Cancer-Kinase/protease |
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