S100A7, Human, mAb 9F3 – 100 µg - HM2328-100UG

Quantity
100 µg
Catalog #
HM2328-100UG
414,00 €
Antibody 9F3 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7 interacts with RAGE which drives an NF-κB mediated proinflammatory response and recruitment of neutrophils.
S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to, and reduces survival of, pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior.
Weitere Informationen
Datasheet URL https://www.hycultbiotech.com/wp-content/uploads/2022/06/coa-tds_hm2328-20ug.pdf
Quantity 100ug
Quantity 100 µg
Species human
Cross reactivity Canine - Yes, Mouse - No, Rabbit - Yes, Rat - Yes, Sheep - Yes
Alias Protein S100-A7, Psoriasin, S100 calcium-binding protein A7
Gene name: S100A7, PSOR1, S100A7C
Application Functional studies, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease Autoimmunity, Tumor immunology
Applications
Application: Functional studies Immuno assays Immuno fluorescence Paraffin sections Western blot

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