S100A7, Human, mAb 9F3 – 100 µg - HM2328-100UG
Quantity
100 µg
Catalog #
HM2328-100UG
414,00 €
Antibody 9F3 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7 interacts with RAGE which drives an NF-κB mediated proinflammatory response and recruitment of neutrophils.
S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to, and reduces survival of, pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior.
S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to, and reduces survival of, pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior.
Datasheet URL | https://www.hycultbiotech.com/wp-content/uploads/2022/06/coa-tds_hm2328-20ug.pdf |
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Quantity | 100ug |
Quantity | 100 µg |
Species | human |
Cross reactivity | Canine - Yes, Mouse - No, Rabbit - Yes, Rat - Yes, Sheep - Yes |
Alias | Protein S100-A7, Psoriasin, S100 calcium-binding protein A7 Gene name: S100A7, PSOR1, S100A7C |
Application | Functional studies, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot |
Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
Disease | Autoimmunity, Tumor immunology |
Application: | Functional studies Immuno assays Immuno fluorescence Paraffin sections Western blot |
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